iBCS Paper 2: Mechanistic Modeling of Pulmonary Availability of Inhaled Drugs versus Critical Product Attributes has Published!

24May2022

This is the second paper in the iBCS series. This publication utilizes mechanistic PBPK modeling to assess the impact of variation in inhaled dose and effective permeability (model inputs) on the rate (half-life) and extent (fraction of the dose absorbed) of drug uptake from the lumen into the lung tissue. The results from this sensitivity analysis are used to identify the classification boundaries of the iBCS grid - which will be described in more detail in the 3rd publication in the series.

This publication and those that will follow in the series are the product of a project supported by PQRI (https://pqri.org/).

Enjoy this Open Access article: https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.2c00112?ref=PDF